Research Information
To assess detoxification efficacy, our medicines were subjected to rigorous trials upon animals of various species before clinical applications.
Alcohol Addiction (Primates)
At first, these medicines were tested for addiction of alcohol in monkeys. To begin with, experimental neurosis was developed in monkeys by subjecting them to neurotogenic trauma. They were served food; and a rubber snake was concealed in their food. While eating, they sighted the rubber snake in their food. They got agitated and refused to eat. By virtue of repetition of this process, neurosis developed in them.
Then, they were given 1.5 ml/kg (body weight) alcohol. This dose of alcohol disintegrated the neurotic complex. Neurotic monkeys, when mildly intoxicated, resumed eating. After experiencing relief from neurotic tension, they preferred taking some alcohol before meals; otherwise, they were unable to take food. Hence, addiction to alcohol developed in them.
These monkeys were divided into two groups. One group was given Detoxin and the other group was given Placebo with following results:
| Group treated with | No. of monkeys treated | Resumed eating without alcohol | Resumed eating but less without alcohol | Did not resume eating |
|---|---|---|---|---|
| Detoxin | 10 | 8 | 1 | 1 |
| Placebo | 10 | Nil | 1 | 9 |
Morphine: Acute Dependence (Mice)
This experiment was conducted upon Albino mice. Samples of 60 Albino mice were taken and were given Morphine HCL 20 mg/kg (body weight). About 4 hours later these mice were divided into two groups. One group was given Detoxin and the other one Placebo. After 5 minutes, both groups were given Nalaxone 5 mg/kg (body weight). Following results observed:
| Group treated with | Total no. of mice | No withdrawals found in | Rearing occurred in | Jumping, urination, defaecation occurred in |
|---|---|---|---|---|
| Detoxin | 30 | 22 | 7 | 1 |
| Placebo | 30 | 3 | 27 | 27 |
Barbiturates (Cats)
For this experiment, samples of 20 cats were taken. They were given Sodium Barbital 95 mg/kg (body weight) two times daily and this dose was increased gradually, until the dose level of Sodium Barbital reached to 200 mg/kg in 180 days. Then, these cats were divided into two groups and were deprived of Sodium Barbital. Thereafter, one group was given Detoxin and Placebo was given to the other group. Following results observed:
| Group treated with | No. of cats | Strong seizures occurred in | Mild seizures occurred in | Seizure occurred in |
|---|---|---|---|---|
| Detoxin | 10 | – | 2 | 8 |
| Placebo | 10 | 9 | 1 | – |
Clinical Trial (Human)
192 cases of addicts of various types were studied. This study was conducted for 1 year. The Observations are as follows:
Age Distribution
Educational Status
Smoking/Chewing Tobacco Study
Another separate study was also conducted in which cases of smoking/chewing tobacco were studied. Details are as follows:
| Type | Addiction Cases | Relapse Cases |
|---|---|---|
| Chewing Tobacco | 95 | 19 |
| Smoking | 531 | 117 |
| Both | 41 | 8 |